Deno is my go to for playing around and hacking now. The out of the box typescript is a huge win. In production apps I have webpack and a whole build process to manage that but hacking around it’s a much better developer experience to just do “deno run index.ts”
In terms of replacing the backend with deno I might consider it but 99% of my backend code is lambda these days and deno doesn’t have first class support yet. Also agree the migration cost is not worth it so deno will need to wait for enough new projects to launch for it to hit critical mass